It's nice having bound the quicksave and quickload keys to a comfortable position. It's also nice that the mouse position is remembered when I click "Yes" after a confirmation pops up after telling ZDoom I want to quicksave or quickload.
What would be even nicer, is an option to skip that very confirmation so I can quicksave just as easily as in any Bethesda game.
Personally, having to hit a confirmatory "Y" when quick saving has never bothered me (indeed, it's stopped me overwriting a save accidentally on more than one occasion) but, as an option, I do see that it would be useful for people who want it.
Interesting to note: These commands are really just binds to the console's save command, with a preset name ("quick"). So suppressing confirmation will affect all uses of console-based saving.
What I'd like to see would be a quickload function that loads the most recent save, using the same logic as when you die. Why? Because I've already remapped my quick save key to use the autosave function (and increased the number of autosave slots from 4 to 10). This way a quicksave doesn't overwrite the previous quicksave. When you've quicksaved a bit too eagerly (such as when you weren't aware there was a rocket inbound less than 10 map units in your back) or when a freeze or crash while saving simply erased your save from existence, it's quite useful to keep the backup.
I might write that one of these days. It doesn't look like it'd be very complicated.
Personally, I like being able to nominate a particular save as the quick one and, just as importantly, being able to change which one is nominated without having an auto replaced limited number of quick saves. I regard it as a strength of the save system.