Buddy Bear - The common mook, they all agree that you're scum who must get a cap in the ass. Fortunately your thick Saiyan skin can handle a few bullets, and unless in swarms they're not much of a threat.
Gumball - A bit more lethal due to the automatic shotgun, if you kill him just right (does pacha gesture) he'll drop a shotgun for you. Plus his big head makes him an easy target.
Lotso Shootan Bear - Even on Easy Mode this strawberry-smelling sod can turn your hide into swiss cheese. However if you take it out, you get a cool chaingun.
Barfbag - An unreasonable, homely facsimilie of Garfield who sounds like a television critic, and vomits acidic hairballs at you. There's a joke in here somewhere, but when you're dead cuz of one of these things, will ya be laughing?
Sweet Bro Prisoner - Comes in two flavours, regular and nightmare. These released prisoners seem to do nothing but mumble about you being useless. Their zig-zaggy patterns can make them hard to hit from afar.
Dontreldemon - Their voice sends chills down your spine, as they spit hot plasma spheres called 'korez' at you. They can also pack a nasty bite at close range. Plus they like to get their slimy skin all over you - so they thrust at you. The joys of this porpoise with a purpose - to spread pure grief.
Hella Jeff Policeman - Arned with a Despairium 45 Rifle and a really goofy voice, this sod is immune to certain weapons, namely the fake axx dorito gas grenades. They also throw doritos at you. Very dangerous. Plus they might be high or something.
BONZIBuddy - You thought this thing died a long time ago. With a ventalator and two banana-arm cannons that shoot pineapples of death at you, plus deadly flames up close, you're best to keep your distance around these malicious apes.
Purrmoids - The powers at be thought turning chorus kids into "cat fingers" was a good idea. Put the poor thing out of it's misery - it's not easy as shooting them with boolets doesn't do anything. You need something more potent to kill them, like rockets or axx spray grenades (or a can of RAID the low irritant kind... /mr. plinkett)
Flaming Flowercrowns - These things lunge at you, and thrust out of the way when shot. They are also relentless at hunting you down. The only good thing is they die easily after a few shotgun blasts.
Dudebronies of Despair - Towering at six feet tall, clad in a "gentlemen's outfit", these blokes aren't fooling anyone. They're dangerous, unlike most bronies. They throw plasma balls at you and can pack a punch with their front hooves.
Checksum Unicorn - These ladies are arguably more dangerous. They shoot hadoughkens, revive other enemies (except dudebronies and bonzi, cuz they're prejudice), and worse yet do some kung-fu moves and become REALLY hard to hit.
(note: at least I'm not picking on anyone)
Junko Trollsona - These alternian troll clones made to resemble the cult leader shoot shrink shots and claw you up badly. Better have some jack and jill pepper on hand if you encounter these denizens.