I personally use Hideous Destructor + Ugly as Sin + Obsidian + DarkDoomZ as a sort of "hardcore tactical survival-horror roguelite". I even have experimented with starting the player on monster spawns for extra replay-ability on the same map (though obviously this breaks easily).
DRPG provide RPG-like leveling and persistent player stats across games, among many other RPG-like things as the name implies. I usually see it paired with DRLA for expanded weapon randomization/modding/upgrading.
There's also Corruption Cards, and Colorful Hell, for gameplay mutators and semi-random monsters. Universal Entropy is another along those lines.
AI Director and Demon Counterstrike provide on-the-fly mob spawns based on timing, player location, health, weaponry, etc.
Last I checked Obsidian can generate boss-type "Gotcha!" or arena levels and unique extra strong "boss" monsters if you enable the right modules (some may be experimental / unstable).
That's just off the top of my head. I know there's a lot
mods more out there focused on providing "semi-universal" gameplay spice which can be mixed and matched, so I'm almost 100% sure that the combination of mods you want exists in some form or another, or at least brings it fairly close.