I just started playing this mod. Haven't been able to use the other weapons much because of Lilk's axe. Between the primary's explosive throw and melee use, and the secondary's homing boomerang act there hasn't been much need of the other weapons, even on nightmare skill. Sometimes I do use the gauntlets when the axe needs a recharge.
Haven't tried it on other maps/monsters yet so maybe the other guns will come into play there.