ZDoom

[quote="Marisa Kirisame"]This is mostly for convenience, as having to set up your desired settings for a mod over and over with each IWAD can get annoying. It would also open the possibility of sharing certain data and information between games, such as stats, achievements, etc.[/quote]

You could add a lump with GZ settings, read that, and set the CVars in your mod. Come to think of it, that may work for all and any mods. I can't think of a way that would make this dynamic when a setting changes, since there's no real file I/O... is there?

This is mostly for convenience, as having to set up your desired settings for a mod over and over with each IWAD can get annoying. It would also open the possibility of sharing certain data and information between games, such as stats, achievements, etc.